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Article

Bacterial expression and characterization of human recombinant apolipoprotein(a) kringle IV type 9.

Protein expression and purification - 1 Jul 1998

Chung F Z, Wu L H, Lee H T, Mueller W T, Spahr M A, Eaton S R, Tian Y, Settimi P D, Oxender D L, Ramharack R

Abstract excerpt

Elevated plasma lipoprotein(a) [Lp(a)] is an independent risk factor for several vascular diseases. Lp(a) particles are generated through the formation of a disulfide bond between Cys4057 of kringle IV type 9, (KIVt9), of the multikringle apolipoprotein(a) [apo(a)] and a cysteine in apoB-100 low-density lipoprotein (LDL). To better understand this interaction, we have expressed and purified KIVt9 from Escherichia...

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PMID: 9675066
DOI: 10.1006/prep.1998.0898

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