Article
The CTLA4 region as a general autoimmunity factor: an extended pedigree provides evidence for synergy with the HLA locus in the etiology of type 1 diabetes mellitus, Hashimoto's thyroiditis and Graves' disease.
European journal of human genetics : EJHG - 1 Jan 2003
Einarsdottir Elisabet, Söderström Ingegerd, Löfgren-Burström Anna, Haraldsson Susann, Nilsson-Ardnor Sofie, Penha-Goncalves Carlos, Lind Lisbet, Holmgren Gösta, Holmberg Monica, Asplund Kjell, Holmberg Dan
Abstract excerpt
We have identified a large family in the northern part of Sweden with multiple cases of autoimmune diseases, namely type 1 diabetes (T1D), Graves' disease (GD) and Hashimoto's thyroiditis (HT). The family members affected by any of these diseases share a region of 2.4 Mb that comprises among others the CTLA4 gene. We determined that all affected members of the family shared the HLA susceptibility haplotype...
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