Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

CRM1/Ran-mediated nuclear export of p27(Kip1) involves a nuclear export signal and links p27 export and proteolysis.

Molecular biology of the cell - 1 Jan 2003

Connor Michael K, Kotchetkov Rouslan, Cariou Sandrine, Resch Ansgar, Lupetti Rafaella, Beniston Richard G, Melchior Frauke, Hengst Ludger, Slingerland Joyce M

Abstract excerpt

We show that p27 localization is cell cycle regulated and we suggest that active CRM1/RanGTP-mediated nuclear export of p27 may be linked to cytoplasmic p27 proteolysis in early G1. p27 is nuclear in G0 and early G1 and appears transiently in the cytoplasm at the G1/S transition. Association of p27 with the exportin CRM1 was minimal in G0 and increased markedly during G1-to-S phase progression. Proteasome...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Active Transport, Cell Nucleus
Share to Cyclin-Dependent Kinase Inhibitor p27

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cysteine Endopeptidases

Share to Exportin 1 Protein

Share to Karyopherins

Share to Multienzyme Complexes

Share to Protein Sorting Signals

Share to ran GTP-Binding Protein

Source

Open in PubMed Open full text

Identifiers

PMID: 12529437
DOI: 10.1091/mbc.e02-06-0319
PMCID: PMC140238

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

CRM1/Ran-mediated nuclear export of p27(Kip1) involves a nuclear export signal and links p27 export and proteolysis.PMID 12529437Read ↗

p27 cytoplasmic localization is regulated by phosphorylation on Ser10 and is not a prerequisite for its proteolysis.Semantic proximity Read ↗

CRM1 Promotes Capsid Disassembly and Nuclear Envelope Translocation of Adenovirus Independently of Its Export Function.Semantic proximity Read ↗

The cyclin-dependent kinase inhibitor p27Kip1 is stabilized in G(0) by Mirk/dyrk1B kinase.Semantic proximity Read ↗

VCP/p97 targets the nuclear export and degradation of p27 Kip1 during G1 to S phase transitionSemantic proximity Read ↗

Cyclin-mediated export of human Orc1.Semantic proximity Read ↗

Cell cycle-dependent translation of p27 involves a responsive element in its 5'-UTR that overlaps with a uORFSemantic proximity Read ↗

Understanding p27<sup>kip1</sup>Deregulation in Cancer: Downregulation or Mislocalizaiton?Semantic proximity Read ↗

Nuclear export of the human cytomegalovirus tegument protein pp65 requires cyclin-dependent kinase activity and the Crm1 exporter.Semantic proximity Read ↗

Translocation of cyclin B1 to the nucleus at prophase requires a phosphorylation-dependent nuclear import signal.Semantic proximity Read ↗

Dynamics of the subcellular localization of RalBP1/RLIP through the cell cycle: the role of targeting signals and of protein-protein interactions.Semantic proximity Read ↗

Extra‐cell cycle regulatory functions of cyclin‐dependent kinases (<scp>CDK</scp>) and <scp>CDK</scp> inhibitor proteins contribute to brain development and neurological disordersSemantic proximity Read ↗

E2F4 is exported from the nucleus in a CRM1-dependent manner.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.