Article
Ablation of internalization signals in the carboxyl-terminal tail of the cystic fibrosis transmembrane conductance regulator enhances cell surface expression.
The Journal of biological chemistry - 20 Dec 2002
Peter Krisztina, Varga Karoly, Bebok Zsuzsa, McNicholas-Bevensee Carmel M, Schwiebert Lisa, Sorscher Eric J, Schwiebert Erik M, Collawn James F
Abstract excerpt
The cystic fibrosis transmembrane conductance regulator (CFTR) is a chloride channel that undergoes endocytosis through clathrin-coated pits. Previously, we demonstrated that Y1424A is important for CFTR endocytosis (Prince, L. S., Peter, K., Hatton, S. R., Zaliauskiene, L., Cotlin, L. F., Clancy, J. P., Marchase, R. B., and Collawn, J. F. (1999) J. Biol. Chem. 274, 3602-3609). Here we show that a second...
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