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Article

Colonic epithelial expression of ErbB2 is required for postnatal maintenance of the enteric nervous system.

Neuron - 9 Jan 2003

Crone Steven A, Negro Alejandra, Trumpp Andreas, Giovannini Marco, Lee Kuo-Fen

Abstract excerpt

We utilized the Cre-LoxP system to establish erbB2 conditional mutant mice in order to investigate the role of erbB2 in postnatal development of the enteric nervous system. The erbB2/nestin-Cre conditional mutants exhibit retarded growth, distended colons, and premature death, resembling human Hirschsprung's disease. Enteric neurons and glia are present at birth in the colon of erbB2/nestin-Cre mutants; however,...

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Identifiers

PMID: 12526770
DOI: 10.1016/s0896-6273(02)01128-5

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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