Article
Genetics analysis of mouse mutations Abnormal feet and tail and rough coat, which cause developmental abnormalities and alopecia.
Mammalian genome : official journal of the International Mammalian Genome Society - 1 Dec 2002
Ruvinsky Ilya, Chertkov Olga, Borue Xenia V, Agulnik Sergei I, Gibson-Brown Jeremy J, Lyle Stephen R, Silver Lee M
Abstract excerpt
Mutations in the mouse Brachyury (T) gene are characterized by a dominant reduction of tail length and recessive lethality. Two quantitative trait loci, Brachyury-modifier 1 and 2 (Brm1 and Brm2) are defined by alleles that enhance the short-tail Brachyury phenotype. Here we report on a genetic analysis of a visible dominant mutation Abnormal feet and tail (Aft) located in the vicinity of Brm1. Affected animals...
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