Article
Multiple mutant T alleles cause haploinsufficiency of Brachyury and short tails in Manx cats.
Mammalian genome : official journal of the International Mammalian Genome Society - 1 Oct 2013
Buckingham Kati J, McMillin Margaret J, Brassil Margaret M, Shively Kathryn M, Magnaye Kevin M, Cortes Alejandro, Weinmann Amy S, Lyons Leslie A, Bamshad Michael J
Abstract excerpt
Most mammals possess a tail, humans and the Great Apes being notable exceptions. One approach to understanding the mechanisms and evolutionary forces influencing development of a tail is to identify the genetic factors that influence extreme tail length variation within a species. In mice, the Tailless locus has proven to be complex, with evidence of multiple different genes and mutations with pleiotropic effects...
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