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[Site-directed mutagenesis of atrial natriuretic peptide gene and effect of the mutations on its diuretic activity in nephrotic rats].

Zhonghua yi xue za zhi - 10 Oct 2002

Li Tao, Liang Hongyan, Yan Feng, Lu Shengdong

Abstract excerpt

OBJECTIVE: To prolong the half-life and enhance the biological activity of the human atrial natriuretic peptide (hANP), a peptide hormone, which is synthesized and released mainly by cardiac atrial myocytes and possesses potent natriuretic, diretic, and vasorelaxant properties. METHODS: The site-directed mutation technique based on polymerase chain reaction was performed to get the mutant of the human ANP gene...

Topics

Animals
Atrial Natriuretic Factor
Diuresis
Genetic Therapy
Kidney Diseases
Male
Mutagenesis, Site-Directed
Mutation
Proteinuria
Rats
Rats, Wistar

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 12509936

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