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[Site-directed mutagenesis of atrial natriuretic peptide gene and effect of the mutations on its diuretic activity in nephrotic rats].

Zhonghua yi xue za zhi - 10 Oct 2002

Li Tao, Liang Hongyan, Yan Feng, Lu Shengdong

Abstract excerpt

OBJECTIVE: To prolong the half-life and enhance the biological activity of the human atrial natriuretic peptide (hANP), a peptide hormone, which is synthesized and released mainly by cardiac atrial myocytes and possesses potent natriuretic, diretic, and vasorelaxant properties. METHODS: The site-directed mutation technique based on polymerase chain reaction was performed to get the mutant of the human ANP gene...

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PMID: 12509936

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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