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Article

[Hypotensive effect of encapsulated genetically engineered fibroblasts expressing mutant atrial natriuretic peptide in hypertensive rats].

Zhonghua yi xue za zhi - 25 Aug 2002

Li Tao, Liang Hongyan, Lu Guo, Shi Ruiwen, Lu Shengdong

Abstract excerpt

OBJECTIVE: To study the inhibitive effect of subcutaneous implantation of capsule filled with fibroblasts engineered to secrete the mutant human atrial natriuretic peptide (mhANP) on blood pressure in young spontaneously hypertensive rats (SHR) and to explore the feasibility of gene therapy for the treatment of hypertension. METHODS: A recombinant retroviral vector pLHY24 bearing mhANP cDNA was constructed....

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PMID: 12425814

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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