Article
An L-RNA-based aquaretic agent that inhibits vasopressin in vivo.
Proceedings of the National Academy of Sciences of the United States of America - 28 Mar 2006
Purschke Werner G, Eulberg Dirk, Buchner Klaus, Vonhoff Stefan, Klussmann Sven
Abstract excerpt
A class of diuretic/aquaretic agents based on mirror-image oligonucleotides (so-called Spiegelmers) has been identified. These molecules directly bind and inhibit the neuropeptide vasopressin (AVP). AVP is the major regulatory component of body fluid homeostasis mediated through binding to the renal V(2) receptor. Elevated plasma levels of AVP are implicated in several pathological conditions, mainly...
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