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Article

Low frequency of FAS mutations in Reed-Sternberg cells of Hodgkin's lymphoma.

The American journal of pathology - 1 Jan 2003

Maggio Ewerton M, Van Den Berg Anke, de Jong Debora, Diepstra Arjan, Poppema Sibrand

Abstract excerpt

Reed-Sternberg (RS) cells, the neoplastic elements of Hodgkin's lymphoma (HL), usually lack B-cell receptor expression. Normal germinal center B cells, with lack of or low-affinity B-cell receptor expression, are eliminated via FAS-induced apoptosis. RS cells express FAS, but are rescued from apoptosis by a transforming event. It is known that HL-derived cell lines are resistant to FAS-mediated apoptosis. To...

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Share to Apoptosis
Share to fas Receptor
Share to Gene Rearrangement

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genes, Immunoglobulin

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Source

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Identifiers

PMID: 12507887
DOI: 10.1016/S0002-9440(10)63795-9
PMCID: PMC1851130

Genes

FAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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