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Article

Receptor-dependent regulation of the CYP3A4 gene.

Toxicology - 27 Dec 2002

Gibson G Gordon, el-Sankary Wafaa, Plant Nick J

Abstract excerpt

A CYP3A4 promoter-reporter gene construct has been used to assess the ability of 16 known (in vivo) and putative (in vitro) inducers to transactivate a CYP3A4 reporter gene in HepG2 cells. With the exception of pravastatin, the remaining 15 compounds transactivated the CYP3A4 reporter gene with differing inductive abilities (I(max):EC(50)) over two orders of magnitude, ranging from 1.1 (phenytoin) to 222.9...

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Source

Identifiers

PMID: 12505310
DOI: 10.1016/s0300-483x(02)00281-0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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