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Article

Association between the GCG polymorphism of the selenium dependent GPX1 gene and the risk of young onset prostate cancer.

Prostate cancer and prostatic diseases - 1 Jan 2002

Kote-Jarai Z, Durocher F, Edwards S M, Hamoudi R, Jackson R A, Ardern-Jones A, Murkin A, Dearnaley D P, Kirby R, Houlston R, Easton D F, Eeles R

Abstract excerpt

Epidemiological studies have suggested an association between low selenium levels and the development of prostate cancer. Human cellular glutathione peroxidase I (hGPX1) is a selenium-dependent enzyme that protects against oxidative damage and its peroxidase activity is a plausible mechanism for cancer prevention by selenium. The GPX1 gene has a GCG repeat polymorphism in exon 1, coding for a polyalanine tract of...

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Source

Identifiers

PMID: 12496980
DOI: 10.1038/sj.pcan.4500569

Genes

GPX1
GCG

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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