Article
Relationship between glutathione S-transferase M1, P1 and T1 polymorphisms and early onset prostate cancer.
Pharmacogenetics - 1 Jun 2001
Kote-Jarai Z, Easton D, Edwards S M, Jefferies S, Durocher F, Jackson R A, Singh R, Ardern-Jones A, Murkin A, Dearnaley D P, Shearer R, Kirby R, Houlston R, Eeles R
Abstract excerpt
There is evidence suggesting that polymorphic variations in the glutathione S-transferases (GSTs) are associated with cancer susceptibility. Inter-individual differences in cancer susceptibility may be mediated in part through polymorphic variability in the bioactivation and detoxification of carcinogens. The GSTs have been consistently implicated as cancer susceptibility genes in this context. The GST supergene...
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