Article
Impact of large chromosomal inversions on the adaptation and evolution of Pseudomonas aeruginosa chronically colonizing cystic fibrosis lungs.
Molecular microbiology - 1 Jan 2003
Kresse Andreas U, Dinesh Sriramulu D, Larbig Karen, Römling Ute
Abstract excerpt
Pseudomonas aeruginosa chronically colonizing the lungs of cystic fibrosis (CF) patients undergoes fast evolution leading to clonal divergence. More than half of the genotypes of P. aeruginosa clone C isolates exclusively from CF lung infection exhibit large chromosomal inversions (LCIs). To analyse the impact of LCIs, as a novel mechanism of bacterial adaptation, the underlying molecular mechanism was examined....
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.