Article
Genetic adaptation by Pseudomonas aeruginosa to the airways of cystic fibrosis patients.
Proceedings of the National Academy of Sciences of the United States of America - 30 May 2006
Smith Eric E, Buckley Danielle G, Wu Zaining, Saenphimmachak Channakhone, Hoffman Lucas R, D'Argenio David A, Miller Samuel I, Ramsey Bonnie W, Speert David P, Moskowitz Samuel M, Burns Jane L, Kaul Rajinder, Olson Maynard V
Abstract excerpt
In many human infections, hosts and pathogens coexist for years or decades. Important examples include HIV, herpes viruses, tuberculosis, leprosy, and malaria. With the exception of intensively studied viral infections such as HIV/AIDs, little is known about the extent to which the clonal expansion that occurs during long-term infection by pathogens involves important genetic adaptations. We report here a...
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