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Article

Apolipoprotein E and Reelin ligands modulate tau phosphorylation through an apolipoprotein E receptor/disabled-1/glycogen synthase kinase-3beta cascade.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Feb 2003

Ohkubo Nobutaka, Lee Young-Don, Morishima Atsuyuki, Terashima Toshio, Kikkawa Satoshi, Tohyama Masaya, Sakanaka Masahiro, Tanaka Junya, Maeda Nobuji, Vitek Michael P, Mitsuda Noriaki

Abstract excerpt

Neurofibrillary tangles comprised of highly phosphorylated tau proteins are a key component of Alzheimer's disease pathology. Mice lacking Reelin (Reln), double-knockouts lacking the VLDL receptor (VLDLR) and ApoE receptor2 (ApoER2), and mice lacking disabled-1 (Dab1) display increased levels of phosphorylated tau. Because Reln binds to recombinant ApoE receptors, assembly of a Reln/ApoE-receptor/Dab1 (RAD)...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Glycogen Synthase Kinase 3

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Share to Low Density Lipoprotein Receptor-Related Protein-1

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Source

Identifiers

PMID: 12490540
DOI: 10.1096/fj.02-0434fje

Genes

VLDLR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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