Article
Epidemiologic study of the association of low-Km mitochondrial acetaldehyde dehydrogenase genotypes with blood pressure level and the prevalence of hypertension in a general population.
Hypertension research : official journal of the Japanese Society of Hypertension - 1 Nov 2002
Amamoto Kenji, Okamura Tomonori, Tamaki Shinji, Kita Yoshikuni, Tsujita Yasuyuki, Kadowaki Takashi, Nakamura Yasuyuki, Ueshima Hirotsugu
Abstract excerpt
In Japanese and other Asians, the prevalence of genetically decreased mitochondrial aldehyde dehydrogenase (ALDH2) activity is higher than in Caucasians. The aim of this study was to elucidate the relation between ALDH2 genotypes and blood pressure levels or hypertension in Japanese. After obtaining informed consent for genetic analysis from 917 men and 1,478 women who lived in a mountainous farming region near...
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