Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Polymorphism in ALDH2-genotype in Japanese men and the alcohol-blood pressure relationship.

American journal of hypertension - 1 Nov 1995

Tsuritani I, Ikai E, Date T, Suzuki Y, Ishizaki M, Yamada Y

Abstract excerpt

Aldehyde dehydrogenase with a low Michaelis constant (Km), ALDH2, is a major enzyme involved in the conversion of acetaldehyde, a toxic metabolite of ethanol, into acetic acid in the liver. Inherited deficiency of ALDH2 activity is found in half of Japanese, and is characterized by "Oriental flushing" after alcohol consumption. The aim of the present study is to evaluate the influence of the genetic polymorphism...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alcohol Drinking
Share to Aldehyde Dehydrogenase
Share to Blood Pressure

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Dose-Response Relationship, Drug

Share to ALDH2 gene

Share to Genotype

Share to Polymorphism, Genetic

Source

Identifiers

PMID: 8554727
DOI: 10.1016/0895-7061(95)00222-B

Genes

ALDH2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Polymorphism in ALDH2-genotype in Japanese men and the alcohol-blood pressure relationship.PMID 8554727Read ↗

The aldehyde dehydrogenase 2 gene is a risk factor for hypertension in Japanese but does not alter the sensitivity to pressor effects of alcohol: the Suita study.Semantic proximity Read ↗

Characterization of the three genotypes of low Km aldehyde dehydrogenase in a Japanese population.Semantic proximity Read ↗

Epidemiologic study of the association of low-Km mitochondrial acetaldehyde dehydrogenase genotypes with blood pressure level and the prevalence of hypertension in a general population.Semantic proximity Read ↗

The contribution of polymorphism in the alcohol dehydrogenase beta subunit to alcohol sensitivity in a Japanese population.Semantic proximity Read ↗

Genetic polymorphism of aldehyde dehydrogenase 2 (ALDH2) in a Chinese population: gender, age, culture, and genotypes of ALDH2.Semantic proximity Read ↗

Association of an aldehyde dehydrogenase 2 (ALDH2) gene polymorphism with hyper-low-density lipoprotein cholesterolemia in a Japanese population.Semantic proximity Read ↗

Alcohol and aldehyde dehydrogenase genotypes and drinking behavior in Japanese.Semantic proximity Read ↗

Esophageal cancer and aldehyde dehydrogenase-2 genotypes in Japanese males.Semantic proximity Read ↗

Genotyping of the aldehyde dehydrogenase 2 (ALDH2) gene using the polymerase chain reaction: evidence for single point mutation in the ALDH2 gene of ALDH2-deficiency.Semantic proximity Read ↗

Gene-environmental interaction regarding alcohol-metabolizing enzymes in the Japanese general population.Semantic proximity Read ↗

Involvement of genetic polymorphism of alcohol and aldehyde dehydrogenases in individual variation of alcohol metabolism.Semantic proximity Read ↗

Contribution of genetic polymorphisms in ethanol-metabolizing enzymes to problem drinking behavior in middle-aged Japanese men.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.