Article
The combination of mitochondrial low enzyme-activity aldehyde dehydrogenase 2 allele and superoxide dismutase 2 genotypes increases the risk of hypertension in relation to alcohol consumption.
Pharmacogenetics and genomics - 1 Jan 2013
Nakagawa Takehiro, Kajiwara Ayami, Saruwatari Junji, Hamamoto Ai, Kaku Wataru, Oniki Kentaro, Mihara Shuichi, Ogata Yasuhiro, Nakagawa Kazuko
Abstract excerpt
A cooperative role of mitochondrial aldehyde dehydrogenase 2 (ALDH2) and superoxide dismutase 2 (SOD2) to maintain the vascular function has recently been demonstrated in nitrate tolerance. The present study examined whether the combination of low enzyme-activity variants of ALDH2 and SOD2 increases the risk of hypertension in relation to alcohol consumption. A total of 444 Japanese participants in a...
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