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Article

MDM2 does not influence p53-mediated sensitivity to DNA-damaging drugs.

Molecular cancer therapeutics - 1 Oct 2002

McKenzie Pamela P, McPake Christina R, Ashford Amy A, Vanin Elio F, Harris Linda C

Abstract excerpt

MDM2 inhibits transactivation properties of the tumor suppressor protein p53 by binding to and facilitating proteasomal degradation of p53. Because MDM2 targets p53 for degradation, it was anticipated that cells that overexpress MDM2 would not contain functional wild-type p53 (wtp53). However, p53 and MDM2 in cells with damaged DNA can become phosphorylated, and their binding to each other can become inhibited....

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Source

Identifiers

PMID: 12481433

Genes

MDM2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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