Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Paraoxonase 1 192/55 gene polymorphisms in Alzheimer's disease.

Annals of the New York Academy of Sciences - 1 Nov 2002

Dantoine Thierry F, Drouet Mireille, Debord Jean, Merle Louis, Cogne Michel, Charmes Jean-Pierre

Abstract excerpt

An esterase, paraoxonase 1 (PON1), protects against organophosphate neurotoxicity and decreases lipoprotein oxidation. Two polymorphisms of PON1 [192 (R or Q) and 55 (M or L)] exist and are associated with coronary artery disease. We have previously shown that serum PON1 activity (PON1a) is lower in vascular dementia (VaD) than in Alzheimer's disease (AD), suggesting that PON1a may distinguish VaD from AD. As...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aged, 80 and over
Share to Alzheimer Disease
Share to Aryldialkylphosphatase

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Base Sequence

Share to DNA Primers

Share to Esterases

Share to Polymorphism, Genetic

Share to Sex Characteristics

Source

Identifiers

PMID: 12480756
DOI: 10.1111/j.1749-6632.2002.tb04821.x

Genes

PON1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Paraoxonase 1 192/55 gene polymorphisms in Alzheimer's disease.PMID 12480756Read ↗

Paraoxonase (PON1) phenotype is a better predictor of vascular disease than is PON1(192) or PON1(55) genotype.Semantic proximity Read ↗

Human serum paraoxonase.Semantic proximity Read ↗

Genetic polymorphisms and activity of PON1 in a Mexican population.Semantic proximity Read ↗

Paraoxonase 1 gene polymorphisms and dementia in humans.Semantic proximity Read ↗

Paraoxonase 55 and 192 polymorphism and its relationship to serum paraoxonase activity and serum lipids in Turkish patients with non-insulin dependent diabetes mellitus.Semantic proximity Read ↗

Frequency of paraoxonase 192/55 polymorphism in an Iranian population.Semantic proximity Read ↗

Paraoxonase/arylesterase ratio, PON1 192Q/R polymorphism and PON1 status are associated with increased risk of ischemic stroke.Semantic proximity Read ↗

Serum paraoxonase (PON1) 55 and 192 polymorphism and paraoxonase activity and concentration in non-insulin dependent diabetes mellitus.Semantic proximity Read ↗

Lack of association between Alzheimer's disease and Gln-Arg 192 Q/R polymorphism of the PON-1 gene in an Italian population.Semantic proximity Read ↗

Paraoxonase Gln-Arg(192) and Leu-Met(55) gene polymorphisms and enzyme activity in a population with a low rate of coronary heart disease.Semantic proximity Read ↗

Involvement of paraoxonase 1 genetic variants in Alzheimer's disease neuropathology.Semantic proximity Read ↗

Effect of the molecular polymorphisms of human paraoxonase (PON1) on the rate of hydrolysis of paraoxon.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.