Article
Paraoxonase 1 Q192R (PON1-192) polymorphism is associated with reduced lipid peroxidation in R-allele-carrier but not in QQ homozygous elderly subjects on a tomato-rich diet.
European journal of nutrition - 1 Dec 2002
Bub Achim, Barth Stephan, Watzl Bernhard, Briviba Karlis, Herbert Birgit Maria, Lührmann Petra Maria, Neuhäuser-Berthold Monika, Rechkemmer Gerhard
Abstract excerpt
BACKGROUND: The oxidative modification of LDL is considered to play a central role in the pathogenesis of atherosclerosis and coronary heart disease (CHD). Paraoxonase (PON1) protects LDL from oxidation and may therefore retard the development of atherosclerosis. The PON1-192 polymorphism is associated with diminished PON1 concentrations and an increased risk for CHD in RR-allele subjects. AIM OF THE STUDY: To...
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