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Article

Liddle Syndrome: Review of the Literature and Description of a New Case.

International journal of molecular sciences - 11 Mar 2018

Tetti Martina, Monticone Silvia, Burrello Jacopo, Matarazzo Patrizia, Veglio Franco, Pasini Barbara, Jeunemaitre Xavier, Mulatero Paolo

Abstract excerpt

Liddle syndrome is an inherited form of low-renin hypertension, transmitted with an autosomal dominant pattern. The molecular basis of Liddle syndrome resides in germline mutations of the SCNN1A, SCNN1B and SCNN1G genes, encoding the α, β, and γ-subunits of the epithelial Na⁺ channel (ENaC), respectively. To date, 31 different causative mutations have been reported in 72 families from four continents. The...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 29534496
DOI: 10.3390/ijms19030812
PMCID: PMC5877673

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Source receipt: pubmed, retrieved 7 Sept 2026.

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