Article
No association between high-altitude tolerance and the ACE I/D gene polymorphism.
Medicine and science in sports and exercise - 1 Dec 2002
Dehnert Christoph, Weymann Jörn, Montgomery Hugh E, Woods David, Maggiorini Marco, Scherrer Urs, Gibbs J Simon R, Bärtsch Peter
Abstract excerpt
PURPOSE: The absence (deletion allele [D]) of a 287 base-pair fragment in the ACE gene is associated with higher ACE tissue activity than its presence (insertion allele [I]) and, as such, may enhance vasoconstriction and fluid retention through increased levels of angiotensin II and aldosterone. Because fluid retention is found in acute mountain sickness (AMS) and exaggerated pulmonary hypertension is essential...
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