Article
Isochore chromosome maps of the human genome.
Gene - 30 Oct 2002
Oliver José L, Carpena Pedro, Román-Roldán Ramón, Mata-Balaguer Trinidad, Mejías-Romero Andrés, Hackenberg Michael, Bernaola-Galván Pedro
Abstract excerpt
The human genome is a mosaic of isochores, which are long DNA segments (z.Gt;300 kbp) relatively homogeneous in G+C. Human isochores were first identified by density-gradient ultracentrifugation of bulk DNA, and differ in important features, e.g. genes are found predominantly in the GC-richest isochores. Here, we use a reliable segmentation method to partition the longest contigs in the human genome draft...
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