Article
An isochore transition zone in the NF1 gene region is a conserved landmark of chromosome structure and function.
Genomics - 1 Oct 2005
Schmegner Claudia, Berger Anke, Vogel Walther, Hameister Horst, Assum Günter
Abstract excerpt
The mammalian genome is organized as a mosaic of isochores, stretches of DNA with a distinct sequence composition. Isochores form the basis of the chromosomal banding pattern, which is tightly correlated with a number of structural and functional features. We have recently demonstrated that the transition from a GC-poor isochore to a GC-rich one in the NF1 gene region occurs within 5 kb and demarcates genomic...
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