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DNA repair gene<i>Ercc1</i>is essential for normal spermatogenesis and oogenesis and for functional integrity of germ cell DNA in the mouse

16 Dec 2002

Abstract excerpt

Ercc1 is essential for nucleotide excision repair (NER) but, unlike other NER proteins, Ercc1 and Xpf are also involved in recombination repair pathways. Ercc1 knockout mice have profound cell cycle abnormalities in the liver and die before weaning. Subsequently Xpa and Xpc knockouts have proved to be good models for the human NER deficiency disease, xeroderma pigmentosum, leading to speculation that the...

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PMID: 12466203
DOI: 10.1242/dev.00221

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