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Article

Activation of the cannabinoid CB1 receptor may involve a W6 48/F3 36 rotamer toggle switch.

The journal of peptide research : official journal of the American Peptide Society - 1 Dec 2002

Singh R, Hurst D P, Barnett-Norris J, Lynch D L, Reggio P H, Guarnieri F

Abstract excerpt

The cannabinoid CB1 receptor, a member of the Rhodopsin (Rho) family of G protein coupled receptors (GPCRs), exhibits high levels of constitutive activity. In contrast, Rho exhibits an exquisite lack of constitutive activity. In Rho, W6.48(265) on transmembrane helix 6 (TMH6) is flanked by aromat...

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Identifiers

PMID: 12464114
DOI: 10.1034/j.1399-3011.2002.21065.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-12464114-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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