Article
Carcinogenesis and apoptosis: paradigms and paradoxes.
Carcinogenesis - 1 Oct 2006
Zhivotovsky Boris, Orrenius Sten
Abstract excerpt
Apoptosis is a physiological process of cell elimination, which is important for both maintenance of cellular homeostasis, and cell proliferation and differentiation. Disturbances in the cell death process might lead to uncontrolled cell growth and to tumor formation. In addition, proper function of the apoptotic machinery is critical for tumor susceptibility to treatment. Many pro-apoptotic and anti-apoptotic...
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