Article
Exclusion of CARD15/NOD2 as a candidate susceptibility gene to psoriasis in the Italian population.
European journal of dermatology : EJD - 1 Jan 2000
Borgiani Paola, Vallo Laura, D'Apice Maria Rosaria, Giardina Emiliano, Pucci Sabina, Capon Francesca, Nisticò Steven, Chimenti Sergio, Pallone Francesco, Novelli Giuseppe
Abstract excerpt
Psoriasis is a chronic inflammatory skin disorder showing multifactorial inheritance. Linkage studies have mapped disease susceptibility loci to several genomic regions, including the chromosome 16 interval that contains the CARD15/NOD2 gene. CARD15 has been involved in Crohn's Disease (CD) susceptibility and it has been hypothesised that it may also contribute to the pathogenesis of psoriasis. To test this...
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