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Article

Akt modulates STAT3-mediated gene expression through a FKHR (FOXO1a)-dependent mechanism.

The Journal of biological chemistry - 14 Feb 2003

Kortylewski Marcin, Feld Florian, Krüger Klaus-Dieter, Bahrenberg Gregor, Roth Richard A, Joost Hans-Georg, Heinrich Peter C, Behrmann Iris, Barthel Andreas

Abstract excerpt

The phosphatidylinositol 3-kinase/Akt pathway plays an important role in the signaling of insulin and other growth factors, which reportedly attenuate the interleukin-6 (IL-6)-mediated stimulation of acute phase plasma protein genes. We investigated the effect of the protein kinase Akt on IL-6-mediated transcriptional activation. The transient expression of constitutively active Akt inhibited the IL-6-dependent...

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Source

Identifiers

PMID: 12456685
DOI: 10.1074/jbc.M205403200

Genes

STAT3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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