Article
DNA methylation controls histone H3 lysine 9 methylation and heterochromatin assembly in Arabidopsis.
The EMBO journal - 2 Dec 2002
Soppe Wim J J, Jasencakova Zuzana, Houben Andreas, Kakutani Tetsuji, Meister Armin, Huang Michael S, Jacobsen Steven E, Schubert Ingo, Fransz Paul F
Abstract excerpt
We propose a model for heterochromatin assembly that links DNA methylation with histone methylation and DNA replication. The hypomethylated Arabidopsis mutants ddm1 and met1 were used to investigate the relationship between DNA methylation and chromatin organization. Both mutants show a reduction of heterochromatin due to dispersion of pericentromeric low-copy sequences away from heterochromatic chromocenters....
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