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Article

Natural variation in DNA methylation homeostasis and the emergence of epialleles.

Proceedings of the National Academy of Sciences of the United States of America - 3 Mar 2020

Zhang Yinwen, Wendte Jered M, Ji Lexiang, Schmitz Robert J

Abstract excerpt

In plants and mammals, DNA methylation plays a critical role in transcriptional silencing by delineating heterochromatin from transcriptionally active euchromatin. A homeostatic balance between heterochromatin and euchromatin is essential to genomic stability. This is evident in many diseases and mutants for heterochromatin maintenance, which are characterized by global losses of DNA methylation coupled with...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32071208
DOI: 10.1073/pnas.1918172117
PMCID: PMC7060739

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