Article
The Golgi GDPase of the fungal pathogen Candida albicans affects morphogenesis, glycosylation, and cell wall properties.
Eukaryotic cell - 1 Jun 2002
Herrero Ana B, Uccelletti Daniela, Hirschberg Carlos B, Dominguez Angel, Abeijon Claudia
Abstract excerpt
Cell wall mannoproteins are largely responsible for the adhesive properties and immunomodulation ability of the fungal pathogen Candida albicans. The outer chain extension of yeast mannoproteins occurs in the lumen of the Golgi apparatus. GDP-mannose must first be transported from the cytosol into the Golgi lumen, where mannose is transferred to mannans. GDP is hydrolyzed by a GDPase, encoded by GDA1, to GMP,...
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