Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Toxoplasma gondii cyclic GMP-dependent kinase: chemotherapeutic targeting of an essential parasite protein kinase.

Eukaryotic cell - 1 Jun 2002

Donald Robert G K, Allocco John, Singh Suresh B, Nare Bakela, Salowe Scott P, Wiltsie Judyann, Liberator Paul A

Abstract excerpt

The trisubstituted pyrrole 4-[2-(4-fluorophenyl)-5-(1-methylpiperidine-4-yl)-1H-pyrrol-3-yl]pyridine (compound 1) has in vivo activity against the apicomplexan parasites Toxoplasma gondii and Eimeria tenella in animal models. The presumptive molecular target of this compound in E. tenella is cyclic GMP-dependent protein kinase (PKG). Native PKG purified from T. gondii has kinetic and pharmacologic properties...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antiprotozoal Agents
Share to Catalytic Domain

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cyclic GMP-Dependent Protein Kinases

Share to Gene Targeting

Share to Pyridines

Share to Pyrroles

Share to Toxoplasma

Share to Toxoplasmosis, Animal

Source

Open in PubMed Open full text

Identifiers

PMID: 12455981
DOI: 10.1128/EC.1.3.317-328.2002
PMCID: PMC118020

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Toxoplasma gondii cyclic GMP-dependent kinase: chemotherapeutic targeting of an essential parasite protein kinase.PMID 12455981Read ↗

Bumped Kinase Inhibitors Inhibit both Toxoplasma gondii MAPKL1 and CDPK1Semantic proximity Read ↗

Inhibition of Calcium Dependent Protein Kinase 1 (CDPK1) by Pyrazolopyrimidine Analogs Decreases Establishment and Reoccurrence of Central Nervous System Disease by Toxoplasma gondiiSemantic proximity Read ↗

Chemotherapeutics for Toxoplasma gondii: Molecular Biotargets, Binding Modes, and Structure–Activity Relationship InvestigationsSemantic proximity Read ↗

A Focused Small-Molecule Screen Identifies 14 Compounds with Distinct Effects on Toxoplasma gondiiSemantic proximity Read ↗

Pyridinylimidazole p38 mitogen-activated protein kinase inhibitors block intracellular Toxoplasma gondii replication.Semantic proximity Read ↗

Molecular characterization of a coccidian parasite cGMP dependent protein kinase.Semantic proximity Read ↗

Forward Genetic Screening Identifies a Small Molecule That Blocks Toxoplasma gondii Growth by Inhibiting Both Host- and Parasite-Encoded KinasesSemantic proximity Read ↗

Evaluation of the basic functions of six calcium-dependent protein kinases in Toxoplasma gondii using CRISPR-Cas9 system.Semantic proximity Read ↗

Identification of mutations in TgMAPK1 of Toxoplasma gondii conferring resistance to 1NM-PP1Semantic proximity Read ↗

A single mutation in the gatekeeper residue in TgMAPKL-1 restores the inhibitory effect of a bumped kinase inhibitor on the cell cycle.Semantic proximity Read ↗

Essential role of pyrophosphate homeostasis mediated by the pyrophosphate-dependent phosphofructokinase in Toxoplasma gondii.Semantic proximity Read ↗

Altiratinib blocks Toxoplasma gondii and Plasmodium falciparum development by selectively targeting a spliceosome kinaseSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.