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The STE12α Homolog Is Required for Haploid Filamentation But Largely Dispensable for Mating and Virulence in Cryptococcus neoformans

1 Dec 1999

Abstract excerpt

Cryptococcus neoformans is a fungal pathogen that causes meningitis in immunocompromised hosts. The organism has a known sexual cycle, and strains of the MATalpha mating type are more virulent than isogenic MATa strains in mice, and they are more common in the environment and infected hosts. A C. neoformans homolog of the STE12 transcription factor that regulates mating, filamentation, and virulence in...

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PMID: 10581270
DOI: 10.1093/genetics/153.4.1601

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Related research

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The STE12α Homolog Is Required for Haploid Filamentation But Largely Dispensable for Mating and Virulence in Cryptococcus neoformansPMID 10581270Read ↗

Cryptococcus neoformans STE12alpha regulates virulence but is not essential for mating.Semantic proximity Read ↗

The second STE12 homologue of Cryptococcus neoformans is MATa-specific and plays an important role in virulence.Semantic proximity Read ↗

The Cryptococcus neoformans STE12alpha gene: a putative Saccharomyces cerevisiae STE12 homologue that is mating type specific.Semantic proximity Read ↗

Mapping of the Cryptococcus neoformans MAT α Locus: Presence of Mating Type-Specific Mitogen-Activated Protein Kinase Cascade HomologsSemantic proximity Read ↗

Identification of the MATa mating-type locus of <i>Cryptococcus neoformans</i> reveals a serotype A MATa strain thought to have been extinctSemantic proximity Read ↗

A homolog of Ste6, the a-factor transporter in Saccharomyces cerevisiae, is required for mating but not for monokaryotic fruiting in Cryptococcus neoformans.Semantic proximity Read ↗

Transcription Factor STE12α Has Distinct Roles in Morphogenesis, Virulence, and Ecological Fitness of the Primary Pathogenic YeastCryptococcus gattiiSemantic proximity Read ↗

The Cryptococcus neoformans STE11α gene is similar to other fungal mitogen‐activated protein kinase kinase kinase (MAPKKK) genes but is mating type specificSemantic proximity Read ↗

Mating-type-specific and nonspecific PAK kinases play shared and divergent roles in Cryptococcus neoformans.Semantic proximity Read ↗

An STE12 homolog from the asexual, dimorphic fungus Penicillium marneffei complements the defect in sexual development of an Aspergillus nidulans steA mutant.Semantic proximity Read ↗

Insertional mutagenesis combined with an inducible filamentation phenotype reveals a conserved STE50 homologue in Cryptococcus neoformans that is required for monokaryotic fruiting and sexual reproduction.Semantic proximity Read ↗

Phenotypic characterization of HAM1, a novel mating regulator of the fungal pathogen Cryptococcus neoformans.Semantic proximity Read ↗

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