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Identification of the MATa mating-type locus of <i>Cryptococcus neoformans</i> reveals a serotype A MATa strain thought to have been extinct

19 Dec 2000

Abstract excerpt

Cryptococcus neoformans is an opportunistic fungal pathogen with a defined sexual cycle involving mating between haploid MATa and MATalpha cells. Here we describe the isolation of part of the MATa mating-type locus encoding a Ste20 kinase homolog, Ste20a. We show that the STE20a gene cosegregates with the MATa mating type in genetic crosses, maps within the mating-type locus on a 1.8-Mb chromosome, and is allelic...

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PMID: 11121047
DOI: 10.1073/pnas.97.26.14455

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