Article
Association between the severity of angiographic coronary artery disease and paraoxonase gene polymorphisms in the National Heart, Lung, and Blood Institute-sponsored Women's Ischemia Syndrome Evaluation (WISE) study.
American journal of human genetics - 1 Jan 2003
Chen Qi, Reis Steven E, Kammerer Candace M, McNamara Dennis M, Holubkov Richard, Sharaf Barry L, Sopko George, Pauly Daniel F, Merz C Noel Bairey, Kamboh M Ilyas
Abstract excerpt
Paraoxonase (PON), a high-density lipoprotein-associated enzyme, is believed to protect against low-density lipoprotein oxidation and thus affects the risk of coronary artery disease (CAD). Three polymorphisms in the PON1 (Leu55Met and Gln192Arg) and PON2 (Ser311Cys) genes have been shown to be a...
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