Article
BRCA1 and BRCA2 germline mutations in Sardinian breast cancer families and their implications for genetic counseling.
Annals of oncology : official journal of the European Society for Medical Oncology - 1 Dec 2002
Palmieri G, Palomba G, Cossu A, Pisano M, Dedola M F, Sarobba M G, Farris A, Olmeo N, Contu A, Pasca A, Satta M P, Persico I, Carboni A A, Cossu-Rocca P, Contini M, Mangion J, Stratton M R, Tanda F
Abstract excerpt
BACKGROUND: The Sardinian population is genetically homogeneous and could be useful in understanding better the genetics of a complex disease like breast cancer (BC). PATIENTS AND METHODS: Using a screening assay based on a combination of single-strand conformation polymorphism, denaturing high-performance liquid chromatography and sequence analysis, 47 Sardinian families with three or more BC cases were screened...
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