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Article

Differential effects of HNF-1α mutations associated with familial young-onset diabetes on target gene regulation.

Molecular medicine (Cambridge, Mass.) - 1 Jan 2000

Galán Maria, García-Herrero Carmen-Maria, Azriel Sharona, Gargallo Manuel, Durán Maria, Gorgojo Juan-Jose, Andía Victor-Manuel, Navas Maria-Angeles

Abstract excerpt

Hepatocyte nuclear factor 1-α (HNF-1α) is a homeodomain transcription factor expressed in a variety of tissues (including liver and pancreas) that regulates a wide range of genes. Heterozygous mutations in the gene encoding HNF-1α (HNF1A) cause familial young-onset diabetes, also known as maturity-onset diabetes of the young, type 3 (MODY3). The variability of the MODY3 clinical phenotype can be due to...

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PMID: 21170474
DOI: 10.2119/molmed.2010.00097
PMCID: PMC3060974

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