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Article

Plasmodium falciparum: selection of serine 108 of dihydrofolate reductase during treatment of uncomplicated malaria with co-trimoxazole in Ugandan children.

The American journal of tropical medicine and hygiene - 1 Jul 1999

Jelinek T, Kilian A H, Curtis J, Duraisingh M T, Kabagambe G, von Sonnenburg F, Warhurst D C

Abstract excerpt

In vivo testing for resistance of Plasmodium falciparum to co-trimoxazole (trimethoprim/sulfamethoxazole) was performed in Uganda in 41 children with uncomplicated malaria, and blood samples were screened before and after treatment for polymorphisms in the antifolate target genes for dihydrofolate reductase (DHFR) and dihydropteroate synthetase (DHPS). Selection towards a specific genotype at some codons of the...

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Source

Identifiers

PMID: 10432069
DOI: 10.4269/ajtmh.1999.61.125

Genes

DHFR
DHPS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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