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Article

Correlation between variation of the 3' region of the cagA gene in Helicobacter pylori and disease outcome in Japan.

The Journal of infectious diseases - 1 Dec 2002

Azuma Takeshi, Yamakawa Akiyo, Yamazaki Shiho, Fukuta Kanako, Ohtani Masahiro, Ito Yoshiyuki, Dojo Manabu, Yamazaki Yukinao, Kuriyama Masaru

Abstract excerpt

Genetic diversity within the cag pathogenicity island (PAI) of Helicobacter pylori may have a modifying effect on the pathogenic potential of the infecting strain. The genetic structure of the cag PAI was examined in Japanese isolates. The composition and nucleotide sequences of the cag PAI were quite similar among strains; however, diversity between 2 cag genes (virB10 and cagA) was observed. The variety in the...

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PMID: 12447739
DOI: 10.1086/345374

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