Article
Genomes of the endothelial cell-tropic variant and the parental Toledo strain of human cytomegalovirus are highly divergent.
Journal of medical virology - 1 Jan 2003
Baldanti Fausto, Revello M Grazia, Percivalle Elena, Labò Nazzarena, Gerna Giuseppe
Abstract excerpt
The low-passage Toledo strain of human cytomegalovirus (HCMV) and fresh clinical HCMV isolates have been reported to share the capacity to propagate efficiently in endothelial cell cultures. In the laboratory, however, repeated attempts to adapt the Toledo strain to growth in endothelial cells have been unsuccessful. Southern blot analysis of the entire viral genome and restriction length polymorphism analysis of...
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