Article
Implications of multiple phenotypes observed in prolactin receptor knockout mice.
Frontiers in neuroendocrinology - 1 Apr 2001
Kelly P A, Binart N, Lucas B, Bouchard B, Goffin V
Abstract excerpt
The development of a mouse line deficient in the PRL receptor (PRLR) would be an ideal means to better understand the multiple functions of prolactin. We were worried initially that removal of the PRLR from the mouse genome might be lethal and were surprised to find this not to be the case. We identified numerous deficiencies in PRLR knockout (KO) animals. Female homozygous mice are completely infertile and lack...
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