Article
Antigen levels of the urokinase-type plasminogen activator and its gene polymorphisms in colorectal cancer.
Cancer letters - 8 Jul 2002
Przybyłowska K, Smolarczyk K, Kulig A, Romanowicz-Makowska H, Dziki A, Ulańska J, Pander B, Błasiak J
Abstract excerpt
We analysed the distribution of genotypes of two polymorphisms in the urokinase-type plasminogen activator (uPA) gene: C-->T substitution in exon 6 and T-->C substitution in intron 7 in 52 subjects with colorectal cancer. Genotypes were determined in tumour tissue and distant mucosa samples by allele-specific polymerase chain reaction. The antigen levels of uPA in cancer tissue were higher than in distant mucosa...
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