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Article

Clinical impact of PAI 1 4G/5G gene polymorphism in colorectal carcinoma patients.

Neoplasma - 1 Jan 2013

Halamkova J, Kiss I, Pavlovsky Z, Tomasek J, Jarkovsky J, Cech Z, Bednarova D, Tucek S, Hanakova L, Moulis M, Zavrelova J, Man M, Benda P, Robek O, Kala Z, Penka M

Abstract excerpt

Plasminogen activator ihnibitor (PAI 1) belongs to the plasminogen activator system, which is part of the metastatic cascade and significantly contributes to invasive growth and angiogenesis of malignant tumors. Its plasma level is normally low but 4G/4G homozygotes have higher concentrations of PAI 1. This genotype may be associated with worse prognosis and proximal location of colorectal cancer than 5G/5G...

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Identifiers

PMID: 23259783
DOI: 10.4149/neo_2013_020

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