Article
Rapid assessment of repair of ultraviolet DNA damage with a modified host-cell reactivation assay using a luciferase reporter gene and correlation with polymorphisms of DNA repair genes in normal human lymphocytes.
Mutation research - 30 Nov 2002
Qiao Yawei, Spitz Margaret R, Guo Zhaozheng, Hadeyati Mohammad, Grossman Lawrence, Kraemer Kenneth H, Wei Qingyi
Abstract excerpt
As DNA repair plays an important role in genetic susceptibility to cancer, assessment of the DNA repair phenotype is critical for molecular epidemiological studies of cancer. In this report, we compared use of the luciferase (luc) reporter gene in a host-cell reactivation (HCR) (LUC) assay of repair of ultraviolet (UV) damage to DNA to use of the chloramphenicol (cat) gene-based HCR (CAT) assay we used previously...
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