Article
The human homolog of yeast SEP1 is a novel candidate tumor suppressor gene in osteogenic sarcoma.
Gene - 2 Oct 2002
Zhang Kunbo, Dion Norbert, Fuchs Bruno, Damron Tim, Gitelis Steven, Irwin Ronald, O'Connor Mary, Schwartz Herbert, Scully Sean P, Rock Michael G, Bolander Mark E, Sarkar Gobinda
Abstract excerpt
The hSEP1 gene is the human homolog of yeast SEP1. Yeast SEP1 is a multifunctional gene that regulates a variety of nuclear and cytoplasmic functions including homologous recombination, meiosis, telomere maintenance, RNA metabolism and microtubule assembly. The function of hSEP1 is not known. We show loss or reduced expression of hSEP1 messenger RNA (mRNA) in three of four primary osteogenic sarcoma (OGS)-derived...
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