Epigenetic loss of the familial tumor-suppressor gene exostosin-1 (EXT1) disrupts heparan sulfate synthesis in cancer cells

Abstract excerpt

Germline mutations in the Exostoses-1 gene (EXT1) are found in hereditary multiple exostoses syndrome, which is characterized by the formation of osteochondromas and an increased risk of chondrosarcomas and osteosarcomas. However, despite its putative tumor-suppressor function, little is known of the contribution of EXT1 to human sporadic malignancies. Here, we report that EXT1 function is abrogated in human...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Bone Tumor Diagnosis and Treatments
• Share to Oral and Maxillofacial Pathology
• Share to Sarcoma Diagnosis and Treatment